Furosemide is an effective diuretic (water pill) which is used to remove water and salt from the body. Inside the kidneys, salt (consisting of sodium and chloride), water, along with other small molecules normally are filtered out of the blood and in to the tubules of the kidney. The filtered fluid eventually becomes urine. A lot of the sodium, chloride and water that is filtered from the blood is reabsorbed into the blood ahead of the filtered fluid will become urine and is taken out from the body. Furosemide operates by blocking the absorption of sodium, chloride, and water from your filtered fluid in the kidney tubules, creating a profound improvement in the output of urine (diuresis). The onset of actions after oral administration is within 60 minutes, and the diuresis lasts about 6-8 hours. The start of action after injection is a few minutes and the time of diuresis is 2 hours. The diuretic effect of furosemide may cause exhaustion of sodium, chloride, body water along with other minerals. Therefore, cautious medical supervision is essential during treatment. The FDA approved furosemide in July 1982.
Furosemide is a powerful diuretic that is utilized to manage abnormal build up of fluid and/or swelling (edema) of the body brought on by heart failure, cirrhosis, chronic kidney failure, and also the nephrotic syndrome. It is sometimes used by itself or in conjunction with other blood pressure pills to take care of high blood pressure.
The usual beginning oral dose for treatment of edema in adults is 20-80 mg as a single dose. The same dose or an improved dose may be administered 6-8 hours later. Doses could be increased 20-40 mg every 6-8 hours till the desired effect occurs. The effective dose might be administered once or twice daily. Some people may need 600 mg daily. The commencing oral dose for the children is 2 mg/kg. The beginning dose may be elevated by 1-2 mg/kg every 6 hours until the desired effect is achieved. Doses greater than 6 mg/kg usually are not recommended. The advised dose for treating hypertension is 40 mg two times a day.
Administration of furosemide with aminoglycoside antibiotics (for instance, gentamicin) or [ethacrynic acid (Edecrin) - another diuretic] may cause hearing damage. Furosemide competes with aspirin for eradication in the urine by the kidneys. Concomitant usage of furosemide and aspirin may, thus, cause high blood levels of aspirin and aspirin toxicity. Furosemide could also reduce excretion of lithium (Eskalith, Lithobid) by the kidneys, creating increased blood levels of lithium and possible side effects from lithium. Sucralfate (Carafate) cuts down on the action of furosemide by binding furosemide in the intestine and stopping its absorption into the body. Ingestion of furosemide and sucralfate needs to be separated by two hours.
There are no satisfactory studies of furosemide in women that are pregnant. Furosemide is secreted in breast milk. Nursing mums should avoid breastfeeding while taking furosemide.
Furosemide is a powerful diuretic that is utilized to manage abnormal build up of fluid and/or swelling (edema) of the body brought on by heart failure, cirrhosis, chronic kidney failure, and also the nephrotic syndrome. It is sometimes used by itself or in conjunction with other blood pressure pills to take care of high blood pressure.
The usual beginning oral dose for treatment of edema in adults is 20-80 mg as a single dose. The same dose or an improved dose may be administered 6-8 hours later. Doses could be increased 20-40 mg every 6-8 hours till the desired effect occurs. The effective dose might be administered once or twice daily. Some people may need 600 mg daily. The commencing oral dose for the children is 2 mg/kg. The beginning dose may be elevated by 1-2 mg/kg every 6 hours until the desired effect is achieved. Doses greater than 6 mg/kg usually are not recommended. The advised dose for treating hypertension is 40 mg two times a day.
Administration of furosemide with aminoglycoside antibiotics (for instance, gentamicin) or [ethacrynic acid (Edecrin) - another diuretic] may cause hearing damage. Furosemide competes with aspirin for eradication in the urine by the kidneys. Concomitant usage of furosemide and aspirin may, thus, cause high blood levels of aspirin and aspirin toxicity. Furosemide could also reduce excretion of lithium (Eskalith, Lithobid) by the kidneys, creating increased blood levels of lithium and possible side effects from lithium. Sucralfate (Carafate) cuts down on the action of furosemide by binding furosemide in the intestine and stopping its absorption into the body. Ingestion of furosemide and sucralfate needs to be separated by two hours.
There are no satisfactory studies of furosemide in women that are pregnant. Furosemide is secreted in breast milk. Nursing mums should avoid breastfeeding while taking furosemide.
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